13,14-dihydro-16,16-difluoro Prostaglandin D2
货号：
13612-100ug 基本售价：
434.0 元 规格：
100 ug
产品信息
概述| 货号 | 13612-100ug |
| 描述 | Prostaglandin D2(PGD2) plays important roles in vascular smooth muscle relaxation, the inhibition of platelet aggregation, and anaphylaxis. 13,14-dihydro-16,16-difluoro PGD2 is an analog of PGD2. While its biological activities have not been evaluated, it should be noted that the addition of two electron-withdrawing fluorine atoms has been used to stabilize prostanoids and significantly delay degradation in vivo.1 Importantly, 13,14-dihydro PGE1 has activity that is comparable to that of PGE1, suggesting that this analog of PGD2 could be biologically active.2,3 |
| 别名 | 13,14-dihydro-16,16-difluoro PGD2; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hatano, Y.,Kohli, J.D.,Goldberg, L.I., et al. Vascular relaxing activity and stability studies of 10,10-difluoro-13,14-dehydroprostacyclin. Proceedings of the National Academy of Sciences of the United States of America 77(11), 6846-6850 (1980).
2.Änggård, E. The biological activities of three metabolites of prostaglandin E1. Acta Physiologica Scandinavica 66, 509-510 (1966).
3.Hamberg, M., and Samuelsson, B. On the metabolism of prostaglandins E1 and E2 in man. The Journal of Biological Chemisty 246, 6713-6721 (1971).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 390.5 |
| 分子式 | C20H32F2O5 |
| 稳定性 | ≥ 1 year |
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