| 货号 | 10012577-25mg |
| 描述 | Hydrogen sulfide (H2S) is an endogenously-produced gaseous second messenger that can regulate many physiological processes. Diallyl trisulfide (DATS) is an organic polysulfide compound found in garlic that acts as an H2S donor.1 It reduces the survival of prostate cancer PC-3 cells (IC50 = 22 μM)2 and inhibits the growth of human colon adenocarcinoma HCT15 cells (IC50 = 11.5 μM).3 DATS suppresses the growth of PC-3 xenografts in vivo in mice4 and induces vascular smooth muscle relaxation.1 Garlic extracts also lower cholesterol and there is evidence that DATS can alter the expression of genes and inhibit enzymes that are relevant to cholesterol synthesis.5,6 |
| 别名 | DATS;NSC 651936; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Benavides, G.A.,Squadrito, G.L.,Mills, R.W., et al. Hydrogen sulfide mediates the vasoactivity of garlic. Proceedings of the National Academy of Sciences of the United States of America 104(46), 17977-17982 (2007). 2.Xiao, D.,Choi, S.,Johnson, D.E., et al. Diallyl trisulfide-induced apoptosis in human prostate cancer cells involves c-jun N-terminal kinase and extracellular-signal regulated kinase-mediated phosphorylation of Bcl-2. Oncogene 23, 5594-5606 (2004). 3.Hosono, T.,Fukao, T.,Ogihara, J., et al. Diallyl trisulfide supresses the proliferation and induces apoptosis of human colon cancer cells through oxidative modification of ß-tubulin. The Journal of Biological Chemisty 280(50), 41487-41493 (2005). 4.Xiao, D.,Lew, K.L.,Kim, Y.A., et al. Diallyl trisulfide suppresses growth of PC-3 human prostate cancer xenograft in vivo in association with bax and bak induction. Clinical Cancer Research 12(22), 6836-6843 (2006). 5.Zhou, Z.,Tan, H.L.,Xu, B.X., et al. Microarray analysis of altered gene expression in diallyl trisulfide-treated HepG2 cells. Pharmacological Reports 57, 818-823 (2005). 6.Gupta, N. and Porter, T.D. Garlic and garlic-derived compounds inhibit human squalene monooxygenase. Journal of Nutrition 131, 1662-1667 (2001). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 178.3 |
| 分子式 | C6H10S3 |
| CAS号 | 2050-87-5 |
| 稳定性 | ≥ 1 year |
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