2,3-bis (4-Hydroxyphenyl) Propionitrile
货号：
10008842-5mg 基本售价：
434.0 元 规格：
5 mg
产品信息
概述| 货号 | 10008842-5mg |
| 描述 | 2,3-bis(4-Hydroxyphenyl)propionitrile (DPN) is an estrogen receptor β (ERβ) selective agonist. DPN exhibits a 70-fold higher relative binding affinity for ERβ (18%) versus ERα (0.25%), about 80-fold higher transcriptional potency (EC50 = 0.85 nM versus 66 nM), and 170-fold higher relative potency (4.6% versus 0.025%) in transcription assays.1 Based on this selectivity, DPN is commonly used as a tool to evaluate the biological role of ERβ. |
| 别名 | DPN; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Meyers, M.J.,Sun, J.,Carlson, K.E., et al. Estrogen receptors-β potency-selective ligands: Structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogus. Journal of Medicinal Chemistry 44, 4230-4251 (2001).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 239.3 |
| 分子式 | C15H13NO2 |
| CAS号 | 1428-67-7 |
| 稳定性 | ≥ 2 years |
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