| 货号 | 10008652-1mg |
| 描述 | Vitamin E is a well known antioxidant that exists in eight natural forms: four tocopherols (α, β, δ, and γ) and four tocotrienols (α, β, δ, and γ). α-Tocopherol is the major lipid soluble antioxidant in vivo and protects against lipid peroxidation.1,2 α-CEHC is the major urinary metabolite of α-tocopherol following vitamin E supplementation.3 α-CMBHC is the longer side-chain precursor of α-CEHC and a minor metabolite of α-tocopherol.4,5 HepG2 cells release α-CEHC, α-CMBHC, and α-CMHHC into the medium when treated with all rac α-tocopherol. Pretreatment of Hep-G2 cells with rifampicin, an inducer of the CYP3A family of cytochrome P450s, results in a 5-fold increase in α-CEHC. This indicates that metabolism of α-tocopherol proceeds by initial ω-oxidation to precursors of α-CMBHC followed by β-oxidation to shorter chain metabolites such as α-CEHC.6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kamal-Eldin, A., and Appelqvist, L.Å. The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids 31, 671-701 (1996). 2.Brigelius-Flohé, R., and Traber, M.G. Vitamin E: Function and metabolism. The FASEB Journal 13, 1145-1155 (1999). 3.Traber, M.G.,Elsner, A., and Brigelius-Flohé, R. Synthetic as compared with natural vitamin E is preferentially excreted as α-CEHC in human urine: Studies using deuterated α-tocopheryl acetates. FEBS Letters 437, 145-148 (1998). 4.Pope, S.A.S.,Burtin, G.E.,Clayton, P.T., et al. New synthesis of (±)-α-CMBHC and its confirmation as a metabolite of α-Tocopherol (vitamin E). Bioorganic & Medicinal Chemistry 9, 1337-1343 (2001). 5.Sontag, T.J., and Parker, R.S. Cytochrome P450 ω-hydroxylase pathway of tocopherol catabolism. Novel mechanism of regulation of vitamin E status. The Journal of Biological Chemisty 277(28), 25290-25296 (2002). 6.Birringer, M.,Drogan, D., and Brigelius-Flohé, R. Tocopherols are metabolized in HepG2 cells by side chain ω-oxidation and consecutive β-oxidation. Free Radical Biology & Medicine 31(2), 226-232 (2001). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 320.4 |
| 分子式 | C19H28O4 |
| CAS号 | 1893298 |
| 稳定性 | ≥ 2 years |
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