产品中心
当前位置：首页>产品中心Anti-Reprimo
货号： bs-1885R 基本售价： 780.0 元 规格： 50ul
- 规格：50ul
- 价格：780.00元
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-1885R
- 英文名称
- Reprimo
- 中文名称
- 细胞质内的糖基化蛋白抗体
- 别 名
- Protein reprimo.; reprimo, TP53 dependent G2 arrest mediator candidate; 2410012A13RIK; FLJ90327; MGC109515; REPRIMO; RPRM; RPRM_HUMAN.
- Specific References (1) | bs-1885R has been referenced in 1 publications.[IF=1.28] Buchegger, Kurt, et al. "Immunohistochemical expression of RPRM is associated with low expression of proliferation marker Ki67 in patients with breast cancer." Int J Clin Exp Med 9.2 (2016): 3025-3032. IHC-P ; Human.PubMed:0
- 规格价格
- 50ul/780元购买 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 50ul 100ul 200ul
- 研究领域
- 肿瘤 细胞生物 细胞凋亡 细胞周期蛋白 糖蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Cow, Rabbit,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 12kDa
- 细胞定位
- 细胞浆
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Reprimo:41-109/109
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
Reprimo, also known as TP53 dependent G2 arrest mediator candidate or RPRM, is a 109 amino acid cytoplasmic protein belonging to the Reprimo family, which is involved in the regulation of p53-dependent G2 arrest of the cell cycle. Reprimo may initiate cell cycle arrest by inhibiting CDC2 and nuclear translocation of the CDC2 cyclin B1 complex. A highly glycosylated protein, Reprimo also plays a role in cell cycle surveillance and DNA repair. Hypermethylation of Reprimo can lead to its transcriptional repression, which may increase pathogenesis of some types of human cancers. Reprimo has been identified as a potential biomarker for early detection multiple cancers. The gene encoding Reprimo maps to human chromosome 2, which houses over 1,400 genes and comprises nearly 8% of the human genome.
Function:
May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 comple.
Subcellular Location:
Cytoplasm. Membrane; Single-pass membrane protein (Potential).
Similarity:
Belongs to the reprimo family.
SWISS:
Q9NS64
Gene ID:
56475
Database links:Entrez Gene: 56475Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Reprimo一种新发现的位于细胞质内的糖基化蛋白,在细胞质中占有优势.
有学者认为：Reprimo是胃癌早期检测的潜在生物标记物。
- 产品图片
Paraformaldehyde-fixed, paraffin embedded (Rat liver); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Reprimo) Polyclonal Antibody, Unconjugated (bs-1885R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.