| 货号 | 11686-50mg |
| 描述 | Betulinic acid is a natural plant triterpenoid that is structurally related to mammalian bile acids. It is an agonist of the G protein-coupled bile acid receptor TGR5 (EC50 = 1 µM), which might be linked with its ability to alter gene expression and fatty liver development in cells and mice given ethanol.1,2,3 Betulinic acid also reduces NF-κB signaling and expression of microRNA-33 in LPS-treated macrophages, increasing levels of the ATP-binding cassette (ABC) cholesterol transporter ABCA1.4 It also inhibits replication of HIV-1 (IC50 = 1.4 µM) and has cytotoxic effects against cancer cells.3,5 |
| 别名 | Lupatic acid;NSC 113090; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Genet, C.,Strehle, A.,Schmidt, C., et al. Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: Potential impact in diabetes. Journal of Medicinal Chemistry 53(1), 178-190 (2010). 2.Wan, Y.,Jiang, S.,Lian, L.H., et al. Betulinic acid and betulin ameliorate acute ethanol-induced fatty liver via TLR4 and STAT3 in vivo and in vitro. International Immunopharmacology 17(2), 184-190 (2013). 3.Kashiwada, Y.,Hashimoto, F.,Cosentino, L.M., et al. Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents. Journal of Medicinal Chemistry 39(5), 1016-1017 (1996). 4.Zhao, G.J.,Tang, S.L.,Lv, Y.C., et al. Antagonism of betulinic acid on LPS-mediated inhibition of ABCA1 and cholesterol efflux through inhibiting nuclear factor-kappaB signaling pathway and miR-33 expression. PLoS One 8(9), e474782 (2013). 5.Mullauer, F.B.,Kessler, J.H. and Medema, J.P. Betulin is a potent anti-tumor agent that is enhanced by cholesterol. PLoS One 4(4), (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 纯度 | ≥97% |
| 计算分子量 | 456.7 |
| 分子式 | C30H48O3 |
| CAS号 | 472-15-1 |
| 稳定性 | ≥ 2 years |
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