AZD 7545
货号：
19282-1mg 基本售价：
420.0 元 规格：
1 mg
产品信息
概述| 货号 | 19282-1mg |
| 描述 | AZD 7545 is an inhibitor of pyruvate dehydrogenase (PDH) kinases (PDKs), resulting in an increase in PDH activity with an EC50 value of 5.2 nM for PDK2.1,2 It less potently inhibits PDK1 and PDK3 (IC50s = 87 and 600 nM, respectively).3 AZD 7545 stimulates pyruvate oxidation in rat hepatocytes (EC50 = 105 nM) and significantly elevates muscle PDH activity in obese Zucker rats.1 It elevates postprandial glucose levels and improves the 24 hour glucose profile in obese, insulin-resistant rats, compared with lean counterparts.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mayers, R.M.,Butlin, R.J.,Kilgour, E., et al. AZD7545, a novel inhibitor of pyruvate dehydrogenase kinase 2 (PDHK2), activates pyruvate dehydrogenase in vivo and improves blood glucose control in obese (fa/fa) Zucker rats. Biochemical Society Transactions 31(Pt 6), 1165-1167 (2003).
2.Morrell, J.A.,Orme, J.,Roche, T.E., et al. AZD7545 is a selective inhibitor of pyruvate dehydrogenase kinase 2. Biochemical Society Transactions 31(Pt 6), 1168-1170 (2016).
3.Kato, M.,Li, J.,Chuang, J.L., et al. Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol. Structure 15(8), 992-1004 (2007).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 478.9 |
| 分子式 | C19H18ClF3N2O5S |
| CAS号 | 252017-04-2 |
| 稳定性 | ≥ 2 years |
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