| 货号 | 14583-10mg |
| 描述 | DNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors, respectively versusIC50 = 40 μM for NMDA receptors).1,2,3 This compound has been used to specifically target AMPA and kainate receptor responses and thus differentiate from that of NMDA receptors. DNQX does not stimulate a robust long-term potentiation in the hippocampus.4 |
| 别名 | 6,7-Dinitroquinoxaline-2,3-dione;FG 9041; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Armstrong, N. and Gouaux, E. Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: Crystal structures of the GluR2 ligand binding core. Neuron 28(1), 165-181 (2000). 2.Honoré, T.,Davies, S.N.,Drejer, J., et al. Quinoxalinediones: Potent competitive non-NMDA glutamate receptor antagonists. Science 241(4866), 701-703 (1988). 3.Lee, S.H.,Govindaiah, G. and Cox, C.L. Selective excitatory actions of DNQX and CNQX in rat thalamic neurons. Journal of Neurophysiology 103(4), 1728-1734 (2010). 4.Muller, D.,Joly, M. and Lynch, G. Contributions of quisqualate and NMDA receptors to the induction and expression of LTP. Science 242(4886), 1694-1697 (1988). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 252.1 |
| 分子式 | C8H4N4O6 |
| CAS号 | 2379-57-9 |
| 稳定性 | ≥ 2 years |
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