| 货号 | 9001248-500ug |
| 描述 | D-myo-Inositol-1-phosphate (Ins(1)P1) is a member of the inositol phosphate molecular family of second messengers that play critical roles in intracellular signaling.1,2Ins(1)P1 can be formed by PLC hydrolysis of phosphatidylinositol or by dephosphorylation of polyphosphate inositols such as Ins(1,3)P2 by inositol polyphosphate 3-phosphatase.1 Changes in myo-inositol-1-phosphate synthase activity and inositol levels are induced by lithium and valproate and are associated with bipolar disorder.3,4 Also, cross-regulation occurs between the SUMO and inositol pathways.5 |
| 别名 | Ins(1)P1 (cyclohexyl ammonium salt);1-IP1 (cyclohexyl ammonium salt); |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Majerus, P.W. Inositol phosphate biochemistry. Annual Reviews of Biochemistry 61, 225-250 (1992). 2.Berridge, M.J. Inositol trisphosphate and calcium signalling. Nature 361, 315-325 (1993). 3.Shamir, A.,Shaltiel, G.,Mark, S., et al. Human MIP synthase splice variants in bipolar disorder. Bipolar Disord. 9(7), 766-771 (2007). 4.Hallcher, L.M., and Sherman, W.R. The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain. The Journal of Biological Chemisty 255(22), 10896-10901 (1980). 5.Felberbaum, R.,Wilson, N.R.,Cheng, D., et al. Desumoylation of the endoplasmic reticulum membrane VAP family protein Scs2 by Ulp1 and SUMO regulation of the inositol synthesis pathway. Mol.Cell Biol. 32(1), 64-75 (2012). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 458.5 |
| 分子式 | C6H11O9P • 2C6H14N |
| 稳定性 | ≥ 1 year |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |