| 货号 | 70080-25mg |
| 描述 | Parthenolide is a sesquiterpene lactone from the plant feverfew (T. parthenium). It inhibits the growth of the promastigote form of L. amazonensis(IC50 = 3.6 μg/ml).1 Parthenolide also induces apoptosis in cancer cells, at least in part by inhibiting NF-κB- and STAT-mediated anti-apoptotic gene transcription.2,3 This compound has also been shown to block inflammation by inhibiting signaling through NF-κB.4 Inhibition of NF-κB by parthenolide can be achieved by direct binding of the pattern recognition receptor NOD2 by parthenolide.5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Tiuman, T.S.,Ueda-Nakamura, T.,Cortez, D.A.G., et al. Antileishmanial activity of parthenolide, a sesquiterpene lactone isolated from Tanacetum parthenium. Antimicrobial Agents and Chemotherapy 49(1), 176-182 (2005). 2.Guzman, M.L.,Rossi, R.M.,Karnischky, L., et al. The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells. Blood 105, 4163-4169 (2005). 3.Pajak, B.,Orzechowski, A., and Gajkowska, B. Molecular basis of parthenolide-dependent proapoptotic activity in cancer cells. Folia Histochem.Cytobiol. 46(2), 129-135 (2008). 4.Lopez-Franco, O.,Hernandez-Vargas, P.,Ortiz-Munoz, G., et al. Parthenolide modulates the NF-κB-mediated inflammatory responses in experimental atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology 26, 1864-1870 (2006). 5.Zhao, L.,Lee, J.Y., and Hwang, D.H. Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals. Nutrition Reviews 69(6), 310-320 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 248.3 |
| 分子式 | C15H20O3 |
| CAS号 | 20554-84-1 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |