DK-AH 269
货号：
21425-1mg 基本售价：
420.0 元 规格：
1 mg
产品信息
概述| 货号 | 21425-1mg |
| 描述 | DK-AH 269 blocks hyperpolarization-activated cyclic nucleotide-gated (HCN) channels (IC50 = 0.62 µM in mouse sinoatrial node cells).1 DK-AH 269 slows heart rate by decreasing the spontaneous firing rate of the sinoatrial node in the heart.2 Using telemetric ECG recordings in mice, it reduced heart rate in a dose-dependent fashion with an ED50 of 1.2 mg/kg.1 DK-AH 269 also has proarrhythmic properties at concentrations higher than 5 mg/kg.1 |
| 别名 | Cilobradine; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Stieber, J.,Wieland, K.,Stöckl, G., et al. Bradycardic and proarrhythmic properties of sinus node inhibitors. Molecular Pharmacology 69(4), 1328-1337 (2006).
2.Bois, P.,Chatelier, A.,Bescond, J., et al. Pharmacology of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. Ion channels and their inhibitors 33-51 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 519.1 |
| 分子式 | C28H38N2O5 • HCl |
| CAS号 | 186097-54-1 |
| 稳定性 | ≥ 2 years |
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