货号 | 21307-25mg |
描述 | Canrenone is a mineralocorticoid receptor antagonist that blocks the activity of aldosterone (Item No. 15273).1,2 Aldosterone blockers have been shown to improve cardiac function in patients following chronic heart failure in clinical trials.3 Canrenone is an active metabolite of spironolactone (Item No. 9000324), which is a diuretic.4 Diuretics, including canrenone and spironolactone, have been abused as performance-enhancing drugs and masking agents in sports doping.5 |
别名 | Aldadiene;NSC 261713;SC-9376;SC-14266; |
供应商 | Cayman |
应用文献 | |
1.Corvol, P.,Clair, M.,Oblin, M.E., et al. Mechanism of the antimineralocorticoid effects of spirolactones. Kidney Int. 20(1), 1-6 (1981). 2.Yang, J. and Young, M.J. Mineralocorticoid receptor antagonists-pharmacodynamics and pharmacokinetic differences. Curr. Opin. Pharmacol. 27, 78-85 (2016). 3.Hu, L.J.,Chen, Y.Q.,Deng, S.B., et al. Additional use of an aldosterone antagonist in patients with mild to moderate chronic heart failure: a systematic review and meta-analysis. Br. J. Clin. Pharmacol. 75(5), 1202-1212 (2013). 4.Larik, F.A.,Saaed, A.,Shahzad, D., et al. Synthetic approaches towards the multi target drug spironolactone and its potent analogues/derivatives. Steroids 118, 76-92 (2017). 5.Cadwallader, A.B.,de la Torre, X.,Tieri, A., et al. The abuse of diuretics as performance-enhancing drugs and masking agents in sport doping: Pharmacology, toxicology and analysis. Br. J. Pharmacol. 161(1), 1-16 (2010). | |
运输条件 | Wet ice in continental US; may vary elsewhere |
存放说明 | -20 |
纯度 | ≥98% |
计算分子量 | 340.5 |
分子式 | C22H28O3 |
CAS号 | 976-71-6 |
稳定性 | ≥ 2 years |
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