AVN944
货号：
21284-1mg 基本售价：
420.0 元 规格：
1 mg
产品信息
概述| 货号 | 21284-1mg |
| 描述 | AVN944 is a selective, noncompetitive inhibitor of inosine-5-monophosphate dehydrogenase (IMPDH; Ki = 6-10 nM for both human IMPDH isoforms), a rate-limiting enzyme involved in the de novo synthesis of purine nucleotides.1 Inhibition of IMPDH results in disruption of DNA and RNA synthesis, inhibition of cell proliferation, and the induction of apoptosis. AVN944 has been shown to inhibit the proliferation of multiple myeloma cells in vitro by inducing caspase-independent apoptosis.1 It is also reported to have antitumor properties in androgen-sensitive and androgen-independent prostate cancer cells in vitro.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ishitsuka, K.,Hideshima, T.,Hamasaki, M., et al. Novel inosine monophosphate dehydrogenase inhibitor VX-944 induces apoptosis in multiple myeloma cells primarily via caspase-independent AIF/Endo G pathway. Oncogene 24(38), 5888-5896 (2005).
2.Floryk, D. and Thompson, T.C. Antiproliferative effects of AVN944, a novel inosine 5-monophosphate dehydrogenase inhibitor, in prostate cancer cells. Int. J. Cancer 123(10), 2294-2302 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 477.5 |
| 分子式 | C25H27N5O5 |
| CAS号 | 297730-17-7 |
| 稳定性 | ≥ 2 years |
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