| 货号 | 21219-1mg |
| 描述 | Acetoacetyl coenzyme A (acetoacetyl-CoA) is a precursor to HMG-CoA in the isoprenoid pathway.1,2 It is reversibly converted to acetyl-CoA by acetoacetyl-CoA thiolase in the mitochondria. Acetoacetyl-CoA thiolase (T2) deficiency results in a build-up of ketone bodies leading to intermittent ketoacidosis.3,4 Acetoacetyl-CoA is also an intermediate in the microbial biosynthesis of polyhydroxybutyrate.5 |
| 别名 | Acetoacetyl-CoA; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lynen, F. and Ochoa, S. Enzymes of fatty acid metabolism. Biochem. Biophys. Acta. 12(1-2), 299-314 (1953). 2.Miziorko, H.M. Enzymes of the mevalonate pathway of isoprenoid biosynthesis. Arch. Biochem. Biophys. 505(2), 131-143 (2011). 3.Daum, R.S.,Scriver, C.R.,Mamer, O.A., et al. An inherited disorder of isoleucine catabolism causing accumulation of alpha-methylacetoacetate and alpha-methyl-beta -hydroxybutyrate, and intermittent metabolic acidosis. Pediatr. Res. 7(3), 149-160 (1973). 4.Fukao, T.,Scriver, C.R. and Kondo, N. The clinical phenotype and outcome of mitochondrial acetoacetyl-CoA thiolase deficiency (β-ketothiolase or T2 deficiency) in 26 enzymatically proved and mutation-defined patients. Mol. Genet. Metab. 72(2), 109-114 (2001). 5.Jacquel, N.,Lo, C.-W.,Wei, Y.-H., et al. Isolation and purification of bacterial poly(3-hydroxyalkanoates). Biochem. Eng. J. 39(1), 15-27 (2008). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥96% |
| 计算分子量 | 989.6 |
| 分子式 | C25H37N7O18P3S • 3Na [4H2O] |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |