ML-290
货号：
21134-1mg 基本售价：
420.0 元 规格：
1 mg
产品信息
概述| 货号 | 21134-1mg |
| 描述 | ML-290 is an allosteric agonist of relaxin family peptide receptor 1 (RXFP1; EC50 = 94 nM for human RXFP1).1,2 It displays >15-fold selectivity for RXFP1 over RXFP2.2 ML-290 activates human, rhesus macaque, pig, and rabbit RXFP1 but is weak or inactive at mouse or guinea pig RXFP1.2,3 Through RXFP1, ML-290 increases intracellular cAMP and induces VEGF expression (2.8-fold at 250 nM).2 ML-290 is metabolically stable and displays excellent in vivopharmacokinetics.2 |
| 别名 | RXFP1 Agonist 8; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Diepenhorst, N.A.,Petrle, E.J.,Chen, C.Z., et al. Investigation of interactions at the extracellular loops of the relaxin family peptide receptor 1 (RXFP1). J. Biol. Chem. 289(50), 34938-34952 (2014).
2.Xiao, J.,Chen, C.Z.,Huang, Z., et al. Discovery, optimization, and biological activity of the first potent and selective small-molecule agonist series of human relaxin receptor 1 (RXFP1). Probe Reports from the NIH Molecular Libraries Program (2012).
3.Huang, Z.,Myhr, C.,Bathgate, R.A.D., et al. Activation of relaxin family receptor 1 from different mammalian species by relaxin peptide and small-molecule agonist ML290. Front. Endocrinol. (Lausanne) 6, 128 (2015).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 506.5 |
| 分子式 | C24H21F3N2O5S |
| CAS号 | 1482500-76-4 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
