A-1210477
货号：
21113-1mg 基本售价：
420.0 元 规格：
1 mg
产品信息
概述| 货号 | 21113-1mg |
| 描述 | A-1210477 is an inhibitor of the antiapoptotic Bcl-2 family protein myeloid cell leukemia-1 (Mcl-1; Ki = 0.43 nM and IC50 = 26.2 nM) that demonstrates >100-fold selectivity over other Bcl-2 family members (Kis > 0.66 µM for Bcl-2, Bcl-XL, Bcl-W, and Bfl-1).1,2,3 It has been shown to disrupt the interaction between Mcl-1 and pro-apoptotic BIM, inducing the hallmarks of apoptosis in Mcl-1-dependent multiple myeloma and non-small cell lung cancer cell lines.1,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Leverson, J.D.,Zhang, H.,Chen, J., et al. Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax). Cell Death Dis. 6, e1590 (2015).
2.Bruncko, M.,Wang, L.,Sheppard, G.S., et al. Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity.. J. Med. Chem. 58(5), 2180-2194 (2015).
3.Opfeman, J.T. Attacking cancer’s Achilles heel: Antagonism of anti-apoptotic BCL-2 family members. FEBS J. 283(14), 2661-2675 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 850 |
| 分子式 | C46H55N7O7S |
| CAS号 | 1668553-26-1 |
| 稳定性 | ≥ 2 years |
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