| 货号 | 20952-1mg |
| 描述 | Atosiban is a peptide analog of oxytocin (Item No. 11799) that antagonizes the human oxytocin receptor (Ki = 81 nM).1 It also binds the vasopressin V1a receptor (Ki = 3.5 nM).1 Because of its effects on the oxytocin receptor, atosiban has tocolytic actions in the acute phase of imminent preterm birth.2,3,4 |
| 别名 | Antocin;ORF 22164;RWJ 22164;Tractocile; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Cirillo, R.,Tos, E.G.,Schwarz, M.K., et al. Pharmacology of (2S,4Z)-N-[(2S)-2-hydroxy-2-phenylethyl]-4-(methoxyimino) -1-[(2-methyl[1,1-biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide, a new potent and selective nonpeptide antagonist of the oxytocin receptor. J.Pharmacol. Exp. Ther. 306(1), 253-261 (2003). 2.Lamont, R.F. The development and introduction of anti-oxytocic tocolytics. B. J. O. G. 110 (Suppl 20), 108-112 (2003). 3.Moutquin, J.M.,Sherman, D.,Cohen, H., et al. Double-blind, randomized, controlled trial of atosiban and ritodrine in the treatment of preterm labor: a multicenter effectiveness and safety study. Am. J. Obstet. Gynecol. 182(5), 1191-1199 (2000). 4.Romero, R.,Sibai, B.M.,Sanchez-Ramos, L., et al. An oxytocin receptor antagonist (atosiban) in the treatment of preterm labor: A randomized, double-blind, placebo-controlled trial with tocolytic rescue. Am. J. Obstet. Gynecol. 182(5), 1173-1183 (2000). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 994.2 |
| 分子式 | C43H67N11O12S2 |
| CAS号 | 90779-69-4 |
| 稳定性 | ≥ 2 years |
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