(±)-Necrostatin-2
货号：
20924-1mg 基本售价：
420.0 元 规格：
1 mg
产品信息
概述| 货号 | 20924-1mg |
| 描述 | (±)-Necrostatin-2 is a racemic mixture that inhibits receptor-interacting protein kinase 1 (RIPK1) autophosphorylation in vitro in a dose-dependent manner.1 Treatment with 6 mg/kg/day of (±)-necrostatin-2 prevents TNF-induced mortality in a murine model of systemic inflammatory response syndrome (SIRS). (±)-Necrostatin-2 decreases irradiation-induced lactate dehydrogenase (LDH) release and cell death in murine embryonic Cyt c-/-cells.2 It also prevents angiotensin II-induced elastin degradation and aortic inflammation in a murine abdominal aortic aneurism (AAA) model at a dose of 1.6 mg/kg/day. |
| 别名 | 7-Cl-O-Nec-1;Nec-1s;RIP1 Inhibitor II; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Takahashi, N.,Duprez, L.,Grootjans, S., et al. Necrostatin-1 analogues: Critical issues on the specificity, activity and in vivo use in experimental disease models. Cell Death Dis. 3, e437 (2012).
2.Huang, Z.,Epperly, M.,Watkins, S.C., et al. Necrostatin-1 rescues mice from lethal irradiation. Biochim. Biophys. Acta 1862(4), 850-856 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 277.7 |
| 分子式 | C13H12ClN3O2 |
| CAS号 | 852391-15-2 |
| 稳定性 | ≥ 2 years |
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