Tolcapone
货号：
20768-5mg 基本售价：
420.0 元 规格：
5 mg
产品信息
概述| 货号 | 20768-5mg |
| 描述 | Tolcapone is a reversible inhibitor of catechol-O-methyl transferase (COMT; Ki = 0.3 nM for recombinant COMT), an enzyme that degrades catecholamines, including dopamine and L-DOPA (Item No. 13248).1 Tolcapone crosses the blood brain barrier and can inhibit both peripheral and central COMT activity.2,3 By inhibiting COMT, tolcapone increases L-DOPA efficacy and reduces L-DOPA-induced motor complications in animal models of Parkinson’s disease.2 |
| 别名 | Ro 40-7592; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Männistö, P.T. and Kaakkola, S. Catechol-O-methyltransferase (COMT): Biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors. Pharmacological Reviews 51(4), 593-628 (1999).
2.Espinoza, S.,Managó, F.,Leo, D., et al. Role of catechol-O-methyltransferase (COMT)-dependent processes in Parkinson’s disease and L-DOPA treatment. CNS Neurol.Disord.Drug Targets 11(3), 251-263 (2012).
3.Männistö, P.T.,Tuomainen, P. and Tuominen, R.K. Different in vivo properties of three new inhibitors of catechol O-methyltransferase in the rat. British Journal of Pharmacology 105, 569-574 (1992).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 273.2 |
| 分子式 | C14H11NO5 |
| CAS号 | 134308-13-7 |
| 稳定性 | ≥ 2 years |
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