CD1530
货号：
19062-1mg 基本售价：
420.0 元 规格：
1 mg
产品信息
概述| 货号 | 19062-1mg |
| 描述 | CD1530 is a selective retinoic acid receptor (RARγ) agonist (Kds = 150, 1,500, and 2,750 nM for RARγ, RARβ, and RARα receptors, respectively).1 It demonstrates transcriptional activity at RARγ with an AC50 value of 1.8 nM.1 It has been used in combination with bexarotene (Item No. 11571), a retinoid X receptor agonist, to inhibit oral carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide in a mouse model of human oral-cavity and esophageal squamous-cell carcinoma.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bernard, B.A.,Bernardon, J.M.,Delescluse, C., et al. Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor γ. Biochemical and Biophysical Research Communications 186(2), 977-983 (1992).
2.Tang, X.H.,Osei-Sarfo, K.,Urvalek, A.M., et al. Combination of bexarotene and the retinoid CD1530 reduces murine oral-cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide. Proceedings of the National Academy of Sciences of the United States of America 111(24), 8907-8912 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 398.5 |
| 分子式 | C27H26O3 |
| CAS号 | 107430-66-0 |
| 稳定性 | ≥ 2 years |
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