CFI-400945
货号：
16850-1mg 基本售价：
420.0 元 规格：
1 mg
产品信息
概述| 货号 | 16850-1mg |
| 描述 | CFI-400945 is an orally available, selective inhibitor of polo-like kinase 4 (PLK4; IC50 = 2.8 nM), a unique kinase that regulates centriole duplication during the cell cycle.1 It does not inhibit other members of the PLK family (IC50s > 50 µM for PLK1, PLK2, and PLK3).1 CFI-400945 has been shown to dysregulate centriole duplication, disrupt mitosis, and induce apoptosis in various PLK4-overexpressing breast cancer cells and to reduce tumor growth in mice bearing MDA-MB-468 breast tumor xenografts.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mason, J.M.,Lin, D.C.,Wei, X., et al. Functional characterization of CFI-400945, a polo-like kinase 4 inhibitor, as a potential anticancer agent. Cancer Cell 26(2), 163-176 (2014).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 534.7 |
| 分子式 | C33H34N4O3 |
| CAS号 | 1338800-06-8 |
| 稳定性 | ≥ 2 years |
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