| 货号 | 16041-500mg |
| 描述 | Angiotensin-converting enzyme converts angiotensin I to angiotensin II, a peptide hormone that impacts vascular smooth muscle tone and renal salt exchange, driving hypertension.1 Enalapril is an orally-active ACE inhibitor (IC50 values range from 2 to 800 nM).2,3,4 It has roles in the management of hypertension, congestive heart failure, myocardial infarction, and diabetic nephropathies.1 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Redelinghuys, P.,Nchinda, A.T. and Sturrock, E.D. Development of domain-selective angiotensin I-converting enzyme inhibitors. Annals of the New York Academy of Sciences 1056, 160-175 (2005). 2.Blankley, C.J.,Kaltenbronn, J.S.,DeJohn, D.E., et al. Synthesis and structure-activity relationships of potent new angiotensin converting enzyme inhibitors containing saturated bicyclic amino acids. Journal of Medicinal Chemistry 30(6), 992-998 (1987). 3.Mencel, J.J.,Regan, J.R.,Barton, J., et al. Angiotensin converting enzyme inhibitors. 10. Aryl sulfonamide substituted N-[1-carboxy-3-phenylpropyl]-L-alanyl-L-proline derivatives as novel antihypertensives. Journal of Medicinal Chemistry 33(6), 1606-1615 (1990). 4.Ksander, G.M.,Erion, M.,Yuan, A.M., et al. Dual angiotensin converting enzyme/thromboxane synthase inhibitors. Journal of Medicinal Chemistry 37(12), 1823-1832 (1994). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 376.5 |
| 分子式 | C20H28N2O5 |
| CAS号 | 75847-73-3 |
| 稳定性 | ≥ 2 years |
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