| 货号 | 14908-10mg |
| 描述 | The Src homology region 2 domain-containing phosphatases (SHP) known as SHP-1 and SHP-2 act downstream of receptor and non-receptor tyrosine kinase to modulate signal transduction.1 NSC 87877 is a cell-permeable, inhibitor of both SHP-1 and SHP-2 (IC50 = 355 and 318 nM, respectively).1 It is much less effective against other protein tyrosine phosphatases and the dual-specificity phosphatase 26.1,2 Through its effects on SHP-1 or SHP-2, NSC 87877 blocks epidermal growth factor receptor-induced activation of Ras and ERK1/2 in HEK293 cells, stimulates store-operated calcium entry in response to thrombin in platelets, and increased acetylcholine receptor clustering in myotubes.1,3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Chen, L.,Sung, S.S.,Yip, M.L.R., et al. Discovery of a novel Shp2 protein tyrosine phosphatase inhibitor. Molecular Pharmacology 70(2), 562-570 (2006). 2.Song, M.,Park, J.E.,Park, S.G., et al. NSC-87877, inhibitor of SHP-½ PTPs, inhibits dual-specificity phosphatase 26 (DUSP26). Biochemical and Biophysical Research Communications 381(4), 491-495 (2009). 3.Redondo, P.C.,Harper, A.G.S.,Harper, M.T., et al. hTRPC1-associated α-actinin, and not hTRPC1 itself, is tyrosine phosphorylated during human platelet activation. J.Thromb.Haemost. 5(12), 2478-2483 (2007). 4.Zhao, X.T.,Qian, Y.K.,Chan, A.W.S., et al. Regulation of ACh receptor clustering by the tyrosine phosphatase Shp2. Dev.Neurobiol. 67(13), 1789-1801 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 459.4 |
| 分子式 | C19H13N3O7S2 |
| CAS号 | 56990-57-9 |
| 稳定性 | ≥ 2 years |
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