| 货号 | 14878-1mg |
| 描述 | Because of their antitumor activity via inhibition of DNA synthesis, purine nucleoside derivatives resistant to deamination have been developed for the treatment of various leukemias.1,2 Pentostatin is a purine nucleoside analog that irreversibly inhibits adenosine deaminase (Ki = 0.9 pM) and thus interrupts DNA synthesis in dividing cells.3,4 Pentostatin has been reported to display strong efficacy in the clinical treatment of hairy cell leukemia as well as relapsed chronic lymphocytic leukemia.4,2 |
| 别名 | CI 825;CL 67310465;DCF;Deoxycoformycin;NSC 218321;NSC 247520; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Chao, D.L.S. and Kimball, A.P. Deamination of arabinosyladenine by adenosine deaminase and inhibition by arabinosyl-6-mercaptopurine. Cancer Research 32, 1721-1724 (1972). 2.Tallman, M.S. and Hakimian, D. Purine nucleoside analogs: Emerging roles in indolent lymphoproliferative disorders. Blood 86(7), 2463-2474 (1995). 3.Shewach, D.S.,Krawczyk, S.H.,Acevedo, O.L., et al. Inhibition of adenosine deaminase by azapurine ribonucleosides. Biochemical Pharmacology 44(9), 1697-1700 (1992). 4.Robak, T.,Korycka, A.,Lech-Maranda, E., et al. Current status of older and new purine nucleoside analogues in the treatment of lymphoproliferative diseases. Molecules 14(3), 1183-1226 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 268.3 |
| 分子式 | C11H16N4O4 |
| CAS号 | 53910-25-1 |
| 稳定性 | ≥ 2 years |
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