| 货号 | 14845-500mg |
| 描述 | Myeloperoxidase is an enzyme, produced by neutrophils and other myeloid cells, that is released upon degranulation.1,2 4-Aminobenzoic acid hydrazide (4-ABAH) is an ABAH that specifically and irreversibly inhibits the peroxidation activity of myeloperoxidase (IC50 = 0.3 μM).3,4 This compound can be used with enzyme preparations, in cell cultures, and also in vivo.3,5,6,7 |
| 别名 | 4-ABAH;Myeloperoxidase Inhibitor 1;NSC 640; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Malle, E.,Furtmüller, P.G.,Sattler, W., et al. Myeloperoxidase: A target for new drug development? British Journal of Pharmacology 152, 838-854 (2007). 2.Nicholls, S.J. and Hazen, S.L. Myeloperoxidase, modified lipoproteins and atherogenesis. Journal of Lipid Research 50, S346-S351 (2009). 3.Kettle, A.J.,Gedye, C.A.,Hampton, M.B., et al. Inhibition of myeloperoxidase by benzoic acid hydrazides. Biochemistry Journal 308, 559-563 (1995). 4.Kettle, A.J.,Gedye, C.A. and Winterbourn, C.C. Mechanism of inactivation of myeloperoxidase by 4-aminobenzoic acid hydrazide. Biochemistry Journal 321, 503-508 (1997). 5.Metzler, K.D.,Fuchs, T.A.,Nauseef, W.M., et al. Myeloperoxidase is required for neutrophil extracellular trap formation: Implications for innate immunity. Blood 117(3), 953-959 (2011). 6.Forghani, R.,Wojkiewicz, G.R.,Zhang, Y., et al. Demyelinating diseases: Myeloperoxidase as an imaging biomarker and therapeutic target. Radiology 263(2), 451-460 (2012). 7.Üllen, A.,Singewald, E.,Konya, V., et al. Myeloperoxidase-derived oxidants induce blood-brain barrier dysfunction in vitro and in vivo. PLoS One 8(5), e64034 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 151.2 |
| 分子式 | C7H9N3O |
| CAS号 | 5351-17-7 |
| 稳定性 | ≥ 2 years |
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