| 货号 | 14834-10mg |
| 描述 | Azaserine is a tumor-inhibiting antibiotic isolated from a species of Streptomyces that functions as a glutamine analog.1,2 At 25 μM, it inhibits the glutamine-dependent amidotransferases involved in nucleotide biosynthesis, phosphoribosylformylglycinamidine synthetase and glucosamine-6-phosphate isomerase.2,3 Azaserine also inhibits the hexosamine biosynthetic pathway, which shunts excessive intracellular glucose into the biosynthesis of UDP-N-acetylglucosamine and the formation of O-linked glycoproteins.4 Azaserine has been shown to protect against hyperglycemic endothelial damage through its antioxidant effects.4 |
| 别名 | CI-337;CN 15757;O-Diazoacetyl-L-serine;NSC 742; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Wise, D.R. and Thompson, C.B. Glutamine addiction: A new therapeutic target in cancer. Trends in Biochemical Sciences 35(8), 427-433 (2010). 2.Lyons, S.D.,Sant, M.E. and Christopherson, R.I. Cytotoxic mechanisms of glutamine antagonists in mouse L1210 leukemia. The Journal of Biological Chemisty 265(19), 11377-11381 (1990). 3.King, J.B.,West, M.B.,Cook, P.F., et al. A novel, species-specific class of uncompetitive inhibitors of γ-glutamyl transpeptidase. The Journal of Biological Chemisty 284(14), 9059-9065 (2009). 4.Rajapakse, A.G.,Ming, X.F.,Carvas, J.M., et al. The hexosamine biosynthesis inhibitor azaserine prevents endothelial inflammation and dysfunction under hyperglycemic condition through antioxidant effects. American Journal of Physiology.Heart and Circulatory Physiology 296(3), H815-H822 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 173.1 |
| 分子式 | C5H7N3O4 |
| CAS号 | 115-02-6 |
| 稳定性 | ≥ 2 years |
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