SCH 79797 (hydrochloride)
货号：
14633-1mg 基本售价：
420.0 元 规格：
1 mg
产品信息
概述| 货号 | 14633-1mg |
| 描述 | SCH 79797 is a non-peptide antagonist of proteinase-activated receptor 1 (PAR1).1 It blocks binding of the high affinity thrombin receptor-activating peptide (haTRAP) (IC50 = 70 nM) as well as platelet aggregation induced by either haTRAP or α-thrombin (IC50 = 0.3 and 3 µM, respectively).2 SCH 79797 has no activity against PAR2, PAR4, or other receptors involved in platelet activation.2 It also blocks PAR1 activation on vascular smooth muscle cells and endothelial cells.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ahn, H.S.,Arik, L.,Boykow, G., et al. Structure-activity relationships of pyrroloquinazolines as thrombin receptor antagonists. Bioorganic & Medicinal Chemistry Letters 9(14), 2073-2078 (1999).
2.Ahn, H.S.,Foster, C.,Boykow, G., et al. Inhibition of cellular action of thrombin by N3-cyclopropyl-7-{[4-(1-methylethyl)phenyl]methyl}-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine (SCH 79797), a nonpeptide thrombin receptor antagonist. Biochemical Pharmacology 60(10), 1425-1434 (2000).
3.Lidington, E.A.,Steinberg, R.,Kinderlerer, A.R., et al. A role for proteinase-activated receptor 2 and PKC-ε in thrombin-mediated induction of decay-accelerating factor on human endothelial cells. American Journal of Physiology.Cell Physiology 289(6), 1437-1447 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 444.4 |
| 分子式 | C23H25N5 • 2HCl |
| CAS号 | 1216720-69-2 |
| 稳定性 | ≥ 2 years |
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