| 货号 | 14630-500mg |
| 描述 | Bumetanide is a loop diuretic with good absorption and pharmacodynamic properties.1,2 It acts as an inhibitor of the Na-K-Cl cotransporter 1 (NKCC1) and the kidney-specific NKCC2 (Ki = 0.5 and 59 μM for human and rabbit NKCC1, respectively).3,4 Bumetanide also inhibits several isoforms of carbonic anhydrase.5 |
| 别名 | PF 1593;Ro 10-6338; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ramsay, L.E.,McInnes, G.T.,Hettiarachchi, J., et al. Bumetanide and frusemide: A comparison of dose-response curves in healthy men. British Journal of Clinical Pharmacology 5(3), 243-247 (1978). 2.Marcantonio, L.A.,Auld, W.H.R.,Murdoch, W.R., et al. The pharmacokinetics and pharmacodynamics of the diuretic bumetanide in hepatic and renal disease. British Journal of Clinical Pharmacology 15(2), 245-252 (1983). 3.Horster, M. Embryonic epithelial membrane transporters. American Journal of Physiology.Renal Physiology 279(6), 982-996 (2000). 4.Gillen, C.M.,Brill, S.,Payne, J.A., et al. Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family. The Journal of Biological Chemisty 271(27), 16237-16244 (1996). 5.Temperini, C.,Cecchi, A.,Scozzafava, A., et al. Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct. Bioorganic & Medicinal Chemistry Letters 18(8), 2567-2573 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 364.4 |
| 分子式 | C17H20N2O5S |
| CAS号 | 28395-03-1 |
| 稳定性 | ≥ 2 years |
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