Phenylmethylsulfonyl fluoride
货号：
14333-5g 基本售价：
420.0 元 规格：
5 g
产品信息
概述| 货号 | 14333-5g |
| 描述 | Phenylmethylsulfonyl fluoride (PMSF) is a nonspecific, irreversible inhibitor of serine proteases and other enzymes, including acetylcholinesterase, palmityl coenzyme A deacylase, arylsulfatase A, chymotrypsin, and trypsin.1,2 It is used in protein solublization studies in order to deactivate proteases from digesting proteins of interest after cell lysis. Because PMSF specifically sulfonylates the hydroxal groups of active site serine residues of enzymes, it can be used as a chemical label to identify essential active site serines in an enzyme. PMSF is known to alter the actions of anandamide by blocking its metabolism and can produce cannabinoid effects in mice, including antinociception, hypothermia, and immobility with ED50 values of 86, 224, and 206 mg/kg, respectively.3 |
| 别名 | Benzylsulfonyl fluoride;NSC 88499;PMSF; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kraut, D.,Goff, H.,Pai, R.K., et al. Inactivation studies on acetylcholinesterase with phenylmethylsulfonyl fluoride. Molecular Pharmacology 57(6), 1243-1248 (2000).
2.Raulston, D.L. and Schroepfer, G.J., Jr. Effect of phenylmethylsulfonyl fluoride on sterol biosynthesis in 10,000 x g supernatant fraction of rat liver homogenates. The Journal of Biological Chemisty 256(14), 7173-7176 (1981).
3.Compton, D.R. and Martin, B.R. The effect of the enzyme inhibitor phenylmethylsulfonyl fluoride on the pharmacological effect of anandamide in the mouse model of cannabimimetic activity. Journal of Pharmacology and Experimental Therapeutics 283, 1138-1143 (1997).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 174.2 |
| 分子式 | C7H7FO2S |
| CAS号 | 329-98-6 |
| 稳定性 | ≥ 2 years |
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