Flumazenil
货号：
14252-10mg 基本售价：
420.0 元 规格：
10 mg
产品信息
概述| 货号 | 14252-10mg |
| 描述 | Flumazenil is an imidazobenzodiazepine derivative that competitively inhibits benzodiazepine binding to GABAA receptors with an IC50 value of 2 nM.1 Flumazenil is non-selective for α1, α2, α3, or α5 subunit-containing GABAA receptors and antagonizes the actions of benzodiazepines on the central nervous system without producing the behavioral or neurological effects typical of the benzodiazepines.1,2 Flumazenil has been used to reverse sedation induced by benzodiazepine drugs and has been found to be effective in the treatment of benzodiazepine overdose or withdrawal.3 |
| 别名 | Anexate;Lanexat;Mazicon;Ro 1722;Ro 15-1788;Ro 41-8157;Romazicon; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hunkeler, W.,Möhler, H.,Pieri, L., et al. Selective antagonists of benzodiazepines. Nature 290, 514-516 (1981).
2.Atack, J.R.,Smith, A.J.,Emms, F., et al. Regional differences in the inhibition of mouse in vivo [3H]Ro 15-1788 binding reflect selectivity for α1 versus α2 and α3 subunit-containing GABAA receptors. Neuropsychopharmacology 20(3), 255-262 (1999).
3.Whitwam, J.G. Flumazenil: A benzodiazepine antagonist. BMJ 297, 999-1000 (1988).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 303.3 |
| 分子式 | C15H14FN3O3 |
| CAS号 | 78755-81-4 |
| 稳定性 | ≥ 2 years |
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