| 货号 | 14125-5mg |
| 描述 | Clofarabine is a nucleoside analog that inhibits ribonucleotide reductase and DNA polymerase-α (IC50s = 65 and 3.9 nM, respectively) and is cytotoxic to K562 myelogenous leukemia cells (IC50 = 5 nM).1 It induces apoptosis in primary chronic lymphocytic leukemia cells by directly altering mitochondrial transmembrane potential.2 Clofarabine demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.3,4,5 |
| 别名 | Clolar;Evoltra; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Parker, W.B.,Shaddix, S.C.,Chang, C.H., et al. Effects of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5-triphosphate. Cancer Research 51, 2386-2394 (1991). 2.Genini, D.,Adachi, S.,Chao, Q., et al. Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria. Blood 96(10), 3537-3543 (2000). 3.Yamauchi, T.,Nowak, B.J.,Keating, M.J., et al. DNA repair initiated in chronic lymphocytic leukemia lymphocytes by 4-hydroperoxycyclophosphamide is inhibited by fludarabine and clofarabine. Clinical Cancer Research 7, 3580-3589 (2001). 4.Chiarini, F.,Lonetti, A.,Teti, G., et al. A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia. Oncotarget 3(12), 1615-1628 (2012). 5.Lee, Y.J.,Im, J.H.,Lee, D.M., et al. Synergistic inhibition of mesothelioma cell growth by the combination of clofarabine and resveratrol involves Nrf2 downregulation. BMB Rep. 45(11), 647-652 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 303.7 |
| 分子式 | C10H11ClFN5O3 |
| CAS号 | 123318-82-1 |
| 稳定性 | ≥ 2 years |
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