| 货号 | 13953-1mg |
| 描述 | Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.1,2,3 Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWP-3 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 40 nM.4 IWP-3 inactivates porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion.4 At 5 μM, IWP-3 has been shown to block Wnt-dependent phosphorylation of the low-density lipoprotein receptor-related protein 6 (LRP6) and the scaffold protein Dishevelled, preventing the accumulation of β-catenin.4 By inhibiting Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC50 = 1.2 μM).5 |
| 别名 | Inhibitor of Wnt Production-3; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Clevers, H. Wnt/β-catenin signaling in development and disease. Cell 127, 469-480 (2006). 2.Polakis, P. Wnt signaling and cancer. Genes & Development 14, 1837-1851 (2000). 3.Reya, T. and Clevers, H. Wnt signalling in stem cells and cancer. Nature 434, 834-850 (2005). 4.Chen, B.,Dodge, M.E.,Tang, W., et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nature Chemical Biology 5(2), 100-107 (2009). 5.Willems, E.,Spiering, S.,Davidovics, H., et al. Small molecule inhibitors of the Wnt pathway potently promote cardiomyocytes from human embryonic stem cell derived mesoderm. Circulation Research 109(4), 360-364 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 484.6 |
| 分子式 | C22H17FN4O2S3 |
| CAS号 | 687561-60-0 |
| 稳定性 | ≥ 2 years |
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