| 货号 | 13952-1mg |
| 描述 | Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.1,2,3 Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWP-2 (Item No. 13951) is an inhibitor of Wnt production (IC50 = 27 nM) that inactivates porcupine, a membrane-bound O-acyltransferase whose palmitoylation activity is essential for the signaling ability and secretion of Wnt proteins.4 IWP-2-V2 is a less potent IWP-2 derivative whose chemical structure retains the benzothiazole group of its parent compound.4 It has been used to determine which structural features of IWP-2 are essential for impairing Wnt/β-catenin pathway activity.4 |
| 别名 | Inhibitor of Wnt Production-2-V2; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Clevers, H. Wnt/β-catenin signaling in development and disease. Cell 127, 469-480 (2006). 2.Polakis, P. Wnt signaling and cancer. Genes & Development 14, 1837-1851 (2000). 3.Reya, T. and Clevers, H. Wnt signalling in stem cells and cancer. Nature 434, 834-850 (2005). 4.Chen, B.,Dodge, M.E.,Tang, W., et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nature Chemical Biology 5(2), 100-107 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 480.6 |
| 分子式 | C23H20N4O2S |
| CAS号 | 877618-79-6 |
| 稳定性 | ≥ 2 years |
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