IDE2
货号：
13817-1mg 基本售价：
420.0 元 规格：
1 mg
产品信息
概述| 货号 | 13817-1mg |
| 描述 | IDE2 is a small molecule capable of inducing definitive endoderm from embryonic stem cells. It has been shown to induce the differentiation of Sox17+/FoxA2+-expressing pancreatic progenitors from human and mouse embryonic stems cells (EC50 = 223 nM in vitro) by activating the TGF-β signaling pathway.1 IDE2-derived endodermal cells injected into E8.75 mouse embryos ex vivo have been shown to incorporate into the developing gut tube, contributing to its formation.1 Furthermore, when treated with either indolactam V (Item No. 14647) or a standard regimen of the growth factor FGF-10, retinoic acid, and hedgehog inhibitors, IDE2-induced endodermal cells can form Pdx1-expressing pancreatic progenitors.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Borowiak, M.,Maehr, R.,Chen, S., et al. Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell 4, 348-358 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 240.3 |
| 分子式 | C12H20N2O3 |
| CAS号 | 1136466-93-7 |
| 稳定性 | ≥ 2 years |
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