Sunitinib (malate)
货号：
13159-1mg 基本售价：
420.0 元 规格：
1 mg
产品信息
概述| 货号 | 13159-1mg |
| 描述 | Sunitinib (malate) is a small molecule, multi-targeted receptor tyrosine kinase inhibitor. It potently inhibits signaling through PDGFR, VEGFR, KIT, and FLT3.1 Through these effects, sunitinib (malate) inhibits both tumor cell growth and angiogenesis, leading to reduced tumor vascularization and cancer cell death.2,3 It has been approved by the FDA for the treatment of gastrointestinal stromal tumors and metastatic renal cell carcinoma. |
| 别名 | Sutent™;SU11248; |
性能| 供应商 | Cayman |
| 应用文献 |
1.OFarrell, A.M.,Abrams, T.J.,Yuen, H.A., et al. SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood 101, 3597-3605 (2003).
2.Mendel, D.B.,Laird, A.D.,Xin, X., et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship. Clinical Cancer Research 9, 327-337 (2003).
3.Motzer, R.J.,Michaelson, M.D.,Redman, B.G., et al. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. Journal of Clinical Oncology 24(1), 16-24 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 532.6 |
| 分子式 | C22H27FN4O2 • C4H6O5 |
| CAS号 | 341031-54-7 |
| 稳定性 | ≥ 2 years |
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