Clozapine
货号：
12059-50mg 基本售价：
420.0 元 规格：
50 mg
产品信息
概述| 货号 | 12059-50mg |
| 描述 | Clozapine is a partial agonist at the 5-HT1A receptor (pKi = 7) and interferes to a lesser extent with the binding of dopamine at D1, D2, D3, and D5 receptors, yet has a high affinity for the D4receptor.1 It is also a strong antagonist at different subtypes of adrenergic, cholinergic, and histaminergic receptors. Clozapine induces the release of glutamate and D-serine, an agonist at the glycine site of the NMDA receptor, from astrocytes, and reduces the expression of astrocytic glutamate transporters.2 |
| 别名 | Azaleptin;Fazaclo;HF 1854;Iprox;Sizopin; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Millan, M.J. Improving the treatment of Schizophrenia: focus on serotonin (5-HT)1A receptors. Journal of Pharmacology and Experimental Therapeutics 295(3), 853-861 (2000).
2.Tanahashi, S.,Yamamura, S.,Nakagawa, M., et al. Clozapine, but not haloperidol, enhances glial D-serin and L-glutamate release in rat frontal cortex and primary cultured astrocytes. British Journal of Pharmacology 165, 1543-1555 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 326.8 |
| 分子式 | C18H19ClN4 |
| CAS号 | 5786-21-0 |
| 稳定性 | ≥ 2 years |
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