| 货号 | 11097-5mg |
| 描述 | 25-hydroxy Cholesterol is a side-chain substituted oxysterol derived from dietary cholesterol that inhibits the cleavage of sterol regulatory element binding proteins (SREBPs) to suppress endogenous cholesterol synthesis in various cell types.1 It has been implicated in a variety of metabolic events including cholesterol homeostasis and atherosclerosis as well as antitumor activities as it has been shown to induce apoptosis through down-regulation of Bcl-2 expression and activation of caspases.2 Immunomodulating capabilities have also been observed as the oxysterol can act as a LXR-RXR ligand coupling cholesterol synthesis to T cell proliferation, can reduce (EC50 ~ 65 nM) IgA production by B cells in response to IL-2, and can suppress differentiation of monocytes into macrophages.3,4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Adams, C.M.,Reitz, J.,De Brabander, J.K., et al. Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs. The Journal of Biological Chemisty 279(50), 52772-52780 (2004). 2.Bischoff, P.L.,Holl, V.,Coelho, D., et al. Apoptosis at the interface of immunosuppressive and anticancer activities: The examples of two classes of chemical inducers, oxysterols and alkylating agents. Curr. Med. Chem. 7(7), 693-713 (2000). 3.McDonald, J.G. and Russell, D.W. Editorial: 25-Hydroxycholesterol: A new life in immunology. Journal of Leukocyte Biology 88(6), 1071-1072 (2010). 4.Bauman, D.R.,Bitmansour, A.D.,McDonald, J.G., et al. 25-Hydroxycholesterol secreted by macrophages in response to toll-like receptor activation suppresses immunoglobulin A production. Proceedings of the National Academy of Sciences of the United States of America 106(39), 16764-16769 (2009). 5.Bensinger, S.J.,Bradley, M.N.,Joseph, S.B., et al. LXR signaling couples sterol metabolism to proliferation in the acquired immune response. Cell 134, 97-111 (2008). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 402.7 |
| 分子式 | C27H46O2 |
| CAS号 | 2140-46-7 |
| 稳定性 | ≥ 2 years |
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