SC-66
货号：
10876-5mg 基本售价：
420.0 元 规格：
5 mg
产品信息
概述| 货号 | 10876-5mg |
| 描述 | Akt activation requires binding of its pleckstrin homology domain (PHD) to membrane-associated phosphatidylinositol-3,4,5-trisphosphate (PIP3) or phosphatidylinositol-3,4-bisphosphate (PIP2).1 Increased Akt activity, e.g., through a gain-of-function mutation in the PHD of Akt1, is pivotal to many types of cancer.2 Activated Akt may be regulated by various events, including ubiquitination-mediated deactivation. SC-66 is an allosteric inhibitor of Akt that facilitates both ubiquitination and deactivation of Akt.3 At 4 μg/ml, SC-66 inhibits Akt activity in HEK293T cells and in HEK293 cells stably expressing Akt with the gain-of-function pleckstrin homology domain mutation, promoting cell death.3 In nude mice inoculated with HEK293T cells, SC-66 (15 mg/kg) suppresses tumor growth.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hennessy, B.T.,Smith, D.L.,Ram, P.T., et al. Exploiting the PI3K/AKT pathway for cancer drug discovery. Nature Reviews.Drug Discovery 4, 988-1004 (2005).
2.Carpten, J.D.,Faber, A.L.,Horn, C., et al. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 448, 439-444 (2007).
3.Jo, H.,Lo, P.K.,Li, Y., et al. Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination. Proceedings of the National Academy of Sciences of the United States of America 108(16), 6486-6491 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 276.3 |
| 分子式 | C18H16N2O |
| CAS号 | 871361-88-5 |
| 稳定性 | ≥ 2 years |
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