| 货号 | 10790-1mg |
| 描述 | Muscarinic receptors are G protein-coupled acetylcholine receptors that play diverse roles. Xanomeline (oxalate) is a potent agonist of muscarinic acetylcholine receptors (EC50 values are 0.3, 92.5, 5, 52, and 42 nM for M1, M2, M3, M4, and M5, respectively).1 It has antipsychotic-like activities in rats and Cebusmonkeys.2,3M1 selective agonists, like Xanomeline (oxalate), enhance memory function and has utility in treating Alzheimer’s Disease.4 |
| 别名 | Lumeron;LY246708;Memcor; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Heinrich, J.N.,Butera, J.A.,Carrick, T., et al. Pharmacological comparison of muscarinic ligands: Historical versus more recent muscarinic M1-preferring receptor agonists. European Journal of Pharmacology 605, 53-56 (2009). 2.Stanhope, K.J.,Mirza, N.R.,Dickerdike, M.J., et al. The muscarinic receptor agonist xanomeline has an antipsychotic-like profile in the rat. Journal of Pharmacology and Experimental Therapeutics 299(2), 782-792. 3.Andersen, M.B.,Fink-Jensen, A.,Peacock, L., et al. The muscarinic M1/M4 receptor agonist xanomeline exhibits antipsychotic-like activity in Cebus apella monkeys. Neuropsychopharmacology 28(6), 1168-1175 (2003). 4.Messer, W.S., Jr. The utility of muscarinic agonists in the treatment of Alzheimer’s disease. Journal of Molecular Neuroscience 19(1-2), 187-193 (2002). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 371.5 |
| 分子式 | C14H23N3OS • C2H2O4 |
| CAS号 | 141064-23-5 |
| 稳定性 | ≥ 2 years |
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