IU1
货号：
10617-5mg 基本售价：
420.0 元 规格：
5 mg
产品信息
概述| 货号 | 10617-5mg |
| 描述 | Polybiquitinylation designates proteins for proteasomal degradation. USP14 is one of several deubiquitinating enzymes (DUBs) responsible for shortening proteasome-bound ubiquitin chains, which is known to antagonize the degradation of ubiquitin-protein conjugates.1 IU1 is a reversible, small molecule inhibitor of deubiquitination by USP14 that demonstrates an IC50 value of 4-5 μM.1 IU1 selectively stimulates ubiquitin-dependent protein degradation in vitro at 34 μM and in MEF cells at 50 μM. At 75 μM, IU1 reduces accumulation of oxidized proteins in HEK293 cells, alleviating cytotoxicity induced by oxidative stress.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lee, B.H.,Lee, M.J.,Park, S., et al. Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature 467, 179-184 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 300.4 |
| 分子式 | C18H21FN2O |
| CAS号 | 314245-33-5 |
| 稳定性 | ≥ 2 years |
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