A-922500
货号：
10012708-1mg 基本售价：
420.0 元 规格：
1 mg
产品信息
概述| 货号 | 10012708-1mg |
| 描述 | Diacylglycerol acyltransferases (DGATs) catalyze the final step in triglyceride synthesis. DGAT-1 deficient mice demonstrate a phenotype that is protective against the development of diet-induced obesity (DIO) or insulin resistance, implicating the actions of this enzyme in the development of such metabolic disorders. A-922500 is a potent orally active inhibitor of DGAT-1 activity, inhibiting both human and mouse forms of the enzymes with IC50 values of 7 and 24 nM, respectively.1 When administered at 3 mg/kg to DIO mice, A-922500 conferred significant weight loss within seven days without affecting food intake and significantly reduced plasma and liver triglycerides with chronic dosing.1 A-922500 does not inhibit DGAT-2, ACAT-1, or ACAT-2.1 |
| 别名 | (1R,2R)-2-(4-(3-phenylureido)biphenylcarbonyl)-cyclopentanecarboxylic acid; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Zhao, G.,Souers, A.J.,Voorbach, M., et al. Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor. Journal of Medicinal Chemistry 51, 380-383 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 428.5 |
| 分子式 | C26H24N2O4 |
| CAS号 | 959122-11-3 |
| 稳定性 | ≥ 1 year |
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