CCG-1423
货号：
10010350-5mg 基本售价：
420.0 元 规格：
5 mg
产品信息
概述| 货号 | 10010350-5mg |
| 描述 | The Rho family of small GTPases play an important role in transduction of cell signaling events associated with several human cancers. CCG-1423 is a specific inhibitor of Rho pathway-mediated signaling and activation of serum response factor (SRF) transcription.1 It inhibits SRF-driven luciferase expression in PC-3 cells following stimulation with constitutively active Gα13 with an IC50 value of 1 µM. The site of inhibition in the pathway is not precisely defined but CCG-1423 appears to act on some aspect of the interaction of SRF with its transcriptional cofactor megakaryoblastic leukemia 1 (MKL1) at a point upstream of DNA binding. CCG-1423 selectively inhibits DNA synthesis, proliferation and invasion of Rho-overexpressing cell lines at nanomolar to low micromolar concentrations.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Evelyn, C.R.,Wade, S.M.,Wang, Q., et al. CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling. Molecular Cancer Therapeutics 6(8), 2249-2260 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 454.8 |
| 分子式 | C18H13ClF6N2O3 |
| CAS号 | 285986-88-1 |
| 稳定性 | ≥ 2 years |
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