GW 9508
货号：
10008907-5mg 基本售价：
420.0 元 规格：
5 mg
产品信息
概述| 货号 | 10008907-5mg |
| 描述 | GPR40 (free fatty acid receptor 1; FFAR1) and GPR120 (FFAR4) are G protein-coupled receptors (GPCR) that are activated by medium and long-chain fatty acids. In addition, there is evidence of a link between GPR40 and the ability of fatty acids to acutely potentiate insulin secretion. GW 9508 is a small-molecule agonist of GPR40 and GPR120. Stimulation of intracellular Ca2+ mobilization by GW 9508 in human embryonic kidney (HEK) 293 cells expressing GPR40 and GPR120 was observed with EC50 values of 47 nM and 2.2 µM, respectively.1 GW 9508 dose dependently potentiates glucose-stimulated insulin secretion and the KCl-mediated increase in insulin secretion in MIN6 cells.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Briscoe, C.P.,Peat, A.J.,McKeown, S.C., et al. Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: Identification of agonist and antagonist small molecules. British Journal of Pharmacology 148, 619-628 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 347.4 |
| 分子式 | C22H21NO3 |
| CAS号 | 885101-89-3 |
| 稳定性 | ≥ 1 year |
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