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货号： bs-1875R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-1875R
- 英文名称
- Profilin 2
- 中文名称
- 前纤维蛋白2抗体
- 别 名
- D3S1319E; PFL; PFN 2; PFN2; Profilin II; Profilin-2; Profilin 2; Profilin2; ProfilinII; Profilin II; Profilin-II; PFN2; PROF2_HUMAN
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 细胞生物 神经生物学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Pig, Cow,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 16kDa
- 细胞定位
- 细胞浆
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Profilin 2:51-140/140
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
Profilin 2 is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals by binding to actin (1:1 ratio) and so affecting the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Highly expressed in skeletal muscle, kidney and brain and less strongly in placenta, heart, liver and lung.
Function:
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Subunit:
Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.
Subcellular Location:
Cytoplasm, cytoskeleton.
Tissue Specificity:
Highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver.
Similarity:
Belongs to the profilin family.
SWISS:
Q9EPC6
Gene ID:
5217
Database links:Entrez Gene: 5217 Human
Entrez Gene: 18645 Mouse
Entrez Gene: 81531 Rat
Omim: 176590 Human
SwissProt: P35080 Human
SwissProt: Q9JJV2 Mouse
SwissProt: Q9EPC6 Rat
Unigene: 91747 Human
Unigene: 271744 Mouse
Unigene: 203100 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
前纤维蛋白(profilin)是一种低分子量的肌动蛋白结合蛋白, 前纤维蛋白除了能与肌动蛋白结合之外,在分子间相互作用的复杂网络中还起到一个控制中心的作用。
- 产品图片
Paraformaldehyde-fixed, paraffin embedded (Human brain glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Profilin 2) Polyclonal Antibody, Unconjugated (bs-1875R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.