ZLN005 (hydrochloride)
货号：
9002449-5mg 基本售价：
406.0 元 规格：
5 mg
产品信息
概述| 货号 | 9002449-5mg |
| 描述 | Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a tissue-specific and inducible transcriptional coactivator for several nuclear receptors and plays a key role in energy metabolism, hepatic gluconeogenesis, and cholesterol homoeostasis.1 ZLN005 is a small molecule that stimulates the expression of PGC-1α and downstream genes in skeletal muscle cells, improving glucose utilization and fatty acid oxidation at a concentration of 20 μM.2 Chronic administration of 15 mg/kg/day ZLN005 to diabetic db/db mice increased PGC-1α and downstream gene transcription in skeletal muscle, increasing fat oxidation and improving glucose tolerance, pyruvate tolerance, and insulin sensitivity.2 This compound is the hydrochloride salt formulation of ZLN005 (Item No. 14121). |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lin, J.,Handschin, C. and Spiegleman, B.M. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metabolism 1, 361-370 (2005).
2.Zhang, L.N.,Zhou, H.Y.,Fu, Y.Y., et al. Novel small-molecule PGC-1α transcriptional regulator with beneficial effects on diabetic db/db mice. Diabetes 62(4), 1297-1307 (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 286.8 |
| 分子式 | C17H18N2 • HCl |
| 稳定性 | ≥ 2 years |
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