WH-4-023
货号：
9002067-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 9002067-1mg |
| 描述 | WH-4-023 is a selective inhibitor of the Src family of non-receptor tyrosine kinases (IC50s = 2 and 6 nM for Lck and Src, respectively).1,2 It inhibits the related kinases p38α and KDR at >300-fold higher concentrations (IC50s = 1.3 and 0.65 µM, respectively).1 At 1 µM, it has been used in combination with PD 0325901 (Item No. 13034), CHIR99021 (Item No. 13122), and SB-590885 (Item No. 16643) to support self-renewal of naïve human embryonic stem cells.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Martin, M.W.,Newcomb, J.,Nunes, J.J., et al. Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity. J.Med.Chem. 49(16), 4981-4991 (2006).
2.Moroco, J.A.,Baumgartner, M.P.,Rust, H.L., et al. A discovery strategy for selective inhibitors of c-Src in complex with the focal adhesion kinase SH3/SH2-binding region. Chem.Biol.Drug Des. 86(2), 144-155 (2015).
3.Theunissen, T.W.,Powell, B.E.,Wang, H., et al. Systematic identification of culture conditions for induction and maintenance of naive human pluripotency. Cell Stem Cell 15(4), 471-487 (2014).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 568.7 |
| 分子式 | C32H36N6O4 |
| CAS号 | 837422-57-8 |
| 稳定性 | ≥ 2 years |
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