Bromoenol lactone-d7
货号：
9000528-100ug 基本售价：
406.0 元 规格：
100 ug
产品信息
概述| 货号 | 9000528-100ug |
| 描述 | Bromoenol lactone-d7(BEL-d7) contains seven deuterium atoms at the 2, 3, 4, 5, 6, 7, and 8 positions. It is intended for use as an internal standard for the quantification of BEL by GC- or LC-mass spectrometry (MS). BEL is a selective, potent, irreversible, mechanism-based inhibitor of phospholipase A2(iPLA2) with a Ki value of 180 nM.1 It also inhibits macrophage iPLA2 in a concentration-dependent manner with an IC50 value of 60 nM and is an effective enzyme-activated irreversible inhibitor of chymotrypsin (Ki = 636 nM).2,3 |
| 别名 | BEL-d7;Haloenol lactone-d7;HELSS-d7; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hazen, S.L.,Zupan, L.A.,Weiss, R.H., et al. Suicide inhibition of canine myocardial cytosolic calcium-independent phospholipase A2. The Journal of Biological Chemisty 266, 7227-7232 (1991).
2.Ackermann, E.J.,Conde-Frieboes, K. and Dennis, E.A. Inhibition of macrophage Ca2+-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones. The Journal of Biological Chemisty 270, 445-450 (1995).
3.Balsinde, J.,Bianco, I.D.,Ackermann, E.J., et al. Inhibition of calcium-independent phospholipase A2 prevents arachidonic acid incorporation and phospholipid remodeling in P388D1 macrophages. Proceedings of the National Academy of Sciences of the United States of America 92, 8527-8531 (1995).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% deuterated forms (d1-d7) |
| 计算分子量 | 324.2 |
| 分子式 | C16H6D7BrO2 |
| 稳定性 | ≥ 1 year |
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