| 货号 | 90001844-1mg |
| 描述 | Peroxiredoxin-6 (Prdx6) is a bifunctional enzyme that has both non-selenium glutathione peroxidase (Gpx) and phospholipase A2(PLA2) activities.1 Its PLA2 activity is calcium-independent, functions optimally in acidic (pH = 4) conditions, and facilitates the intracellular processing of surfactant lipids, including dipalmitoylphosphatidylcholine (DPPC).1,2,3 MJ33 is a selective, reversible inhibitor of the acidic, calcium-independent (ai)PLA2 activity of Prdx6, with optimal inhibition achieved at an MJ33 concentration of 3 mol%.4,5,6 It blocks the degradation of DPPC in both whole lung and isolated alveolar type II epithelial cells.2 MJ33 has been used to examine the role of Prdx6 PLA2 activity in the activation of type 2 NADPH oxidase and in the regulation of Prdx6 PLA2 activity by phosphorylation.7,8 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Chen, J.W.,Dodia, C.,Feinstein, S.I., et al. 1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities. The Journal of Biological Chemisty 275(37), 28421-28427 (2000). 2.Fisher, A.B.,Dodia, C.,Feinstein, S.I., et al. Altered lung phospholipid metabolism in mice with targeted deletion of lysosomal-type phospholipase A2. Journal of Lipid Research 46(6), 1248-1256 (2005). 3.Fisher, A.B. and Dodia, C. Role of acidic Ca2+-independent phospholipase A2 in synthesis of lung dipalmitoyl phosphatidylcholine. American Journal of Physiology 272, L238-L243 (1997). 4.Fisher, A.B. and Dodia, C. Role of phospholipase A2 enzymes in degradation of dipalmitoylphosphatidylcholine by granular pneumocytes. Journal of Lipid Research 37, 1057-1064 (1996). 5.Kim, T.S.,Sundaresh, C.S.,Feinstein, S.I., et al. Identification of a human cDNA clone for lysosomal type Ca2+-independent phospholipase A2 and properties of the expressed protein. The Journal of Biological Chemisty 272, 2542-2550 (1997). 6.Fisher, A.B.,Dodia, C.,Chander, A., et al. A competitive inhibitor of phospholipase A2 decreases surfactant phosphatidylcholine degradation by the rat lung. Biochemistry Journal 288(Pt 2), 407-411 (1992). 7.Lee, I.,Dodia, C.,Chatterjee, S., et al. Protection against LPS-induced acute lung injury by a mechanism-based inhibitor of NADPH oxidase (type 2). American Journal of Physiology.Lung Cellular and Molecular Physiology 306, L635-L644 (2014). 8.Wu, Y.,Feinstein, S.I.,Manevich, Y., et al. Mitogen-activated protein kinase-mediated phosphorylation of peroxiredoxin 6 regulates its phospholipase A2 activity. Biochem. 419(3), 669-679 (2009). | |
| 运输条件 | Wet Ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 498.5 |
| 分子式 | C22H43F3O6P • Li |
| CAS号 | 1007476-63-2 |
| 稳定性 | ≥ 2 years |
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