U-0126
货号：
70970-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 70970-1mg |
| 描述 | U-0126 is a selective MAP Kinase Kinase (MKK, MEK) inhibitor with IC50 values of 72 nM and 58 nM for MEK1 and MEK2, respectively.1 It shows little to no inhibition against a number of other kinases including PKC, Ab1, Raf, MEKK, ERK, JNK, MKK-3, MKK-4, MKK-6, Cdk2, and Cdk4. U-0126 inhibition of MEK is noncompetitive with respect adenosine triphosphate (ATP) and its phosphorylation target ERK, which may partially explain its selectivity profile against other kinases.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Favata, M.F.,Horiuchi, K.Y.,Manos, E.J., et al. Identification of a novel inhibitor of mitogen-activated protein kinase kinase*. The Journal of Biological Chemisty 273 (29), 18623-18632 (1998).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 380.5 |
| 分子式 | C18H16N6S2 |
| CAS号 | 109511-58-2 |
| 稳定性 | ≥ 2 years |
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