| 货号 | 21817-1mg |
| 描述 | Siramesine is an agonist of the sigma-2 (σ2) receptor (IC50 = 0.19 nM).1 It is selective for σ2 over σ1(IC50 = 17 nM) and related receptors and transporters.1 Siramesine is anxiolytic without inducing sedation or impairing motor coordination in animal studies.1 It is known to induce the death of cancer cells in vitro by destabilizing lysosomes, although it has also been shown to destabilize mitochondria and, with lapatinib (Item No. 11493), induce ferroptosis.2,3,4 |
| 别名 | Lu 28-179; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Sánchez, C.,Arnt, J.,Costall, B., et al. The selective σ2-ligand Lu 28-179 has potent anxiolytic-like effects in rodents. J. Pharmacol. Exp. Ther. 283(3), 1323-1332 (1997). 2.Česen, M.H.,Repnik, U.,Turk, V., et al. Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Cell Death Dis. 4(10), e818 (2013). 3.Ma, S.,Henson, E.S.,Chen, Y., et al. Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells. Cell Death Dis. 7(7), e2307 (2016). 4.Ostenfeld, M.S.,Fehrenbacher, N.,Høyer-Hansen, M., et al. Effective tumor cell death by σ-2 receptor ligand siramesine involves lysosomal leakage and oxidative stress. Cancer Res. 65(19), 8975-8983 (2005). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 570.7 |
| 分子式 | C30H31FN2O • C4H4O4 |
| CAS号 | 163630-79-3 |
| 稳定性 | ≥ 2 years |
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